WebKcsA ( K c hannel von s treptomyces A) ist ein prokaryotischer Kaliumkanal aus dem Bodenbakterium Streptomyces lividans, der in der Ionenkanalforschung eingehenduntersucht wurde.Das pH- aktivierte Protein besitzt zwei Transmembransegmente und eine hochselektive Porenregion, die für das Ansteuern und Versetzen von K + … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Visualizza altro hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Visualizza altro Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to Visualizza altro This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in decreased … Visualizza altro The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Visualizza altro A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved by electron microscopy. In the laboratory the Visualizza altro Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued … Visualizza altro HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Visualizza altro
State dependent dissociation of HERG channel inhibitors.
WebDer HERG-Kanal (Abk. für engl. Human Ether-A-Go-Go Related Gen) ist ein Kaliumkanal in Herzmuskelzellen. Der Kanal besteht aus sechs Transmembrandomänen und ist für … WebThe human ether-à-go-go -related potassium channel (hERG, Kv11.1) is a voltage-dependent channel known for its role in repolarizing the cardiac action potential. hERG alteration by mutation or pharmacological … communicant\u0027s w4
HERG - DocCheck Flexikon
http://www.kanalk.ch/ WebExperimental approach: HERG channels were expressed heterologously in Xenopus oocytes and currents were measured with the two-electrode voltage clamp technique. Key results: Frequency-dependent block was observed for amiodarone, cisapride, droperidol and haloperidol (group 1) whereas bepridil, domperidone, E-4031 and terfenadine (group 2) … Web12 feb 2024 · Der hERG ist die α-Untereinheit des gleichnamigen hERG-Kanals, der hauptsächlich in Kardiomyozyten vorkommt. Es handelt sich dabei um einen … communicant\u0027s wa