WebMETAL is a tool for performing meta-analysis of p-values from two or more individual studies. Metal creates a single summary p-value from studies which could not be ... For A/C, A/G, C/T, and G/T SNPs, METAL will flip the strand the alleles are on if not consistent between input files and METAL will output results with respect to the lowest ... WebSeveral practical questions, such as advantages of meta-analysis over conventional narrative review and the number of studies required for a meta-analysis, are addressed. Common meta-analytic models are then introduced. An artificial dataset is used to illustrate how a meta-analysis is conducted in several software packages.
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WebNov 15, 2024 · Meta-analysis an important strategy for genetic association studies. Increases sample size and power. Can lead to discovery of novel loci. Can use previously published study results. What happens if different studies in the meta-analysis have samples in common? We wish to estimate the ‘bottom-line’ p-value that corrects for … http://csg.sph.umich.edu/abecasis/Metal/download/metal-instructions.pdf blocca tastiera windows
Including a study with an opposite outcome direction in meta …
WebMETAL is a tool for performing meta-analysis of p-values from two or more individual studies. Metal creates a single summary p-value from studies which could not be ... For … WebThe METAL software is designed to facilitate meta-analysis of large datasets (such as several whole genome scans) in a convenient, rapid and memory efficient manner. This website includes a download page, brief documentation in our wiki and a registration page. If you use Metal please fill out a copy of the registration form or e-mail Goncalo ... METAL is a tool for meta-analysis genomewide association scans. METAL can combine either (a) test statistics and standard errors or (b) p-values across studies (taking sample size and direction of effect into … See more There are a few pages in this Wiki that may be useful to METAL users. Here are links to key pages: 1. The METAL Home Page 1. The METAL … See more METAL was developed by Goncalo Abecasis, Yun Li and Cristen Willer (manuscript available here). The first version was developed in 2007 and was used for the … See more One of the most common questions we receive is about the approach used by METAL to carry out a meta-analysis using p-values as input. The process is actually quite simple! First, for each marker, a reference allele is … See more free backup for wordpress