WebJul 1, 2014 · The T cell-surface glycoprotein CD6 is a modulator of cellular responses and has been implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis. During Ag presentation, CD6 is targeted to the immunological synapse in a ligand binding-dependent manner, … WebCD6 is a cell surface glycoprotein that functions both as a co-stimulatory and adhesion receptor on T cells. Recently we have described CD6 isoforms (CD6a, b, c, d, e) that arise via alternative splicing of exons encoding the cytoplasmic region of the molecule.
Analysis of the tyrosine phosphorylation and calcium fluxing of …
WebMar 21, 2024 · CD6 (CD6 Molecule) is a Protein Coding gene. Diseases associated with CD6 include Inflammatory Bowel Disease 16 and Multiple Sclerosis . Gene Ontology (GO) annotations related to this gene include scavenger receptor activity . An important paralog of this gene is DMBT1. UniProtKB/Swiss-Prot Summary for CD6 Gene WebCD6 DMDM 281185506 ClinGen HGNC:1691 GenCC HGNC:1691 PTM/Processing Features Showing features for signal, chain, glycosylation, disulfide bond, modified residue. Expand table Post-translational modification After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues. 4 … knowlents
Extracellular isoforms of CD6 generated by alternative …
WebCD6 is a transmembrane glycoprotein, mainly expressed by all T cells and a subset of B cells. It has been shown that the human CD6 gene has six reported transcript isoforms, including full length and Δ3 isoforms. These are CD6a, CD6b, CD6c, CD6d, CD6e and CD6Δ3. In every isoform, particular exon(s) … WebApr 29, 2024 · selection a CD6 isoform lacking d3 (CD6∆d3) is also expressed, and is therefore unable to bind to CD166 (43). The alternative splicing event that induces d3 … WebApr 9, 2013 · Kofler et al. have examined the biological phenotype of this risk-associated allele of CD6 in carriers and found a correlation between the presence of the susceptibility allele rs17828933 GG and enrichment of the CD6Δd3 isoform (a natural-occuring isoform lacking CD6-d3 , the ligand-binding domain) in both CD4 and CD8 T cells . There is a ... knowler365 cloudknowler365.com